Studying Alzheimer’s Disease Using <i>Drosophila melanogaster</i> as a Powerful Tool
نویسندگان
چکیده
Background: Alzheimer’s disease (AD) is an increasingly prevalent neurodegenerative characterized by protein aggregation in the form of amyloid plaques containing beta-amyloid peptides and neurofibrillary tangles hyperphosphorylated tau protein. The central molecular events underlying AD pathogenesis remain controversial poorly defined. Drosophila melanogaster has emerged as important genetic resource for studying pathology AD. Many models have been created using Drosophila, taking advantage its short generation times, sophisticated tools, abundance homologs to human genes. Purpose: This review summarizes different melanogaster, including full-length APP, C99, Aβ42 Tau models, explaining how were built what we learned from them. Conclusion: Four main are introduced this review, which can serve a future method investigate genes drugs that modify symptoms.
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ژورنال
عنوان ژورنال: Advances in Alzheimer's disease
سال: 2022
ISSN: ['2210-5727', '2210-5735']
DOI: https://doi.org/10.4236/aad.2022.113003